Patients with an ApoE 4 allele require lower doses of coumarin anticoagulants

Autor: Visser, Loes E., Trienekens, Paul H., Smet, Peter AGM De, Vulto, Arnold G., Hofman, Albert, Duijn, Cornelia M. van, Stricker, Bruno HCh
Zdroj: Pharmacogenetics and Genomics; February 2005, Vol. 15 Issue: 2 p69-74, 6p
Abstrakt: Vitamin K is an essential cofactor for the synthesis of several blood coagulation factors. It has been suggested that the apolipoprotein E (ApoE) genotype has profound effects on vitamin K status. Therefore, we investigated whether this common genetic polymorphism influenced dose requirements and effects of coumarin anticoagulants.
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