| Autor: |
Cole, Toby B, Jampsa, Rachel L, Walter, Betsy J, Arndt, Tara L, Richter, Rebecca J, Shih, Diana M, Tward, Aaron, Lusis, Aldons J, Jack, Rhona M, Costa, Lucio G, Furlong, Clement E |
| Zdroj: |
Pharmacogenetics; June 2003, Vol. 13 Issue: 6 p357-364, 8p |
| Abstrakt: |
Paraoxonase (PON1), a HDL-associated enzyme, protects against toxicity from specific organophosphorus compounds and oxidized lipids. Common polymorphisms in the PON1gene have been identified and characterized in the coding region, 5′ regulatory region and 3′ UTR. The Q192R coding region polymorphism determines substrate-dependent differences in catalytic efficiency of hydrolysis. The −108CTpolymorphism in the 5′ regulatory region has a significant effect on PON1expression, with the −108Callele expressing on average twice the level of plasma PON1 as the −108Tallele. In addition to the effects of regulatory and coding region polymorphisms on PON1 levels and activity, plasma PON1 levels are also developmentally regulated. Since PON1 levels are important in determining resistance to specific organophosphorus compounds, the time course of appearance of PON1 in newborns is of great interest. |
| Databáze: |
Supplemental Index |
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