| Autor: |
Park, Jong Y., Muscat, Joshua E., Kaur, Tajinder, Schantz, Stimson P., Stern, Jordan C., Richie, John P., Lazarus, Philip |
| Zdroj: |
Pharmacogenetics; March 2000, Vol. 10 Issue: 2 p123-131, 9p |
| Abstrakt: |
Two members of the mu class of glutathione S-transferase (GST) genes, GSTM1and GSTM3, have polymorphic alleles which have been associated with altered levels of GST μ protein expression and may be linked to increased risk for several tobacco-related cancers. Oral cancer is a tobacco-related disease that affects African-American men at a significantly higher incidence than Caucasian men. To examine the potential role of GSTM polymorphisms in risk for oral cancer in African-Americans and Caucasians, the prevalences of the GSTM1null and GSTM3intron 6 polymorphisms were examined in 63 African-American and 101 Caucasian patients with histologically confirmed primary oral cancer, as well as in 133 African-American and 213 Caucasian matched control subjects. In African-Americans, the odds ratio for oral cancer associated with the GSTM1(0/0) genotype was 3.1 95 confidence interval (CI) 1.1–8.5, with the association between the GSTM1(0/0) genotype and oral cancer risk strongest in heavy smokers i.e. > 24 pack-years; odds ratio (OR) 5.4, 95 CI 1.2–24. Using the potentially most protective GSTM1/ GSTM3(B/B) genotype as the reference group, increased risk for oral cancer was observed in African-Americans with the GSTM1/ GSTM3(A/A) (A/B) (OR 2.2, 95 CI 0.82–6.0), GSTM1(0/0)/ GSTM3(B/B) (OR 4.3, 95 CI 1.1–16), and GSTM1(0/0)/ GSTM3(A/A) (A/B) (OR 6.6, 95 CI 1.2–38) genotypes (P< 0.01, trend test). No significant associations were observed between GSTMgenotype and oral cancer risk in Caucasians. These results suggest that the GSTM1null and GSTM3intron 6 polymorphisms play an important role in risk for oral cancer among African-Americans and implicates the mu class of GSTs as important tobacco carcinogen detoxifying enzymes in this population. |
| Databáze: |
Supplemental Index |
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