| Autor: |
Lee, Dean A., Harris, Charles P., Gresik, Vicky M., Rao, Pulivarthi, Lau, Ching C. |
| Zdroj: |
Journal of Pediatric Hematology / Oncology; July 2004, Vol. 26 Issue: 7 p431-434, 4p |
| Abstrakt: |
Granulocytic sarcoma is a soft tissue collection of leukemic cells. The authors describe a 4-year-old boy with M2 acute myelogenous leukemia (AML) who presented with fever, mild nonproductive cough, and hematemesis. Although he was initially diagnosed with nodular pneumonia, rapid resolution of a pulmonary infiltrate following induction chemotherapy was suggestive of a pulmonary granulocytic sarcoma. Interphase fluorescent in situ hybridization (FISH) of the lung biopsy specimen for the t(8;21)(q22;q22) translocation confirmed the retrospective diagnosis of a well-differentiated pulmonary granulocytic sarcoma. Pulmonary granulocytic sarcomas may be underrecognized in children with AML; this may delay anti-leukemic therapy and may lead to ineffective therapy if misdiagnosed as pneumonia. |
| Databáze: |
Supplemental Index |
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