| Autor: |
Nozawa, Fumiaki, Itami, Atsushi, Saruc, Murat, Kim, Min, Standop, Jens, Picha, Kathleen S., Cowan, Kenneth H., Pour, Parviz M. |
| Zdroj: |
Pancreas; July 2004, Vol. 29 Issue: 1 p45-52, 8p |
| Abstrakt: |
Our previous studies have shown that, contrary to many other human pancreatic adenocarcinoma cell lines, AsPC1 cells are resistant to the apoptotic effect of the tumor necrosis factor-related apoptosis-inducing ligand, also called Apo2L (TRAIL/Apo2L). In our in vitro studies, the combination of TRAIL/Apo2L and protein synthesis inhibitor, genistein, but not genistein alone, was, however, effective in inducing apoptosis in AsPC1 cells. In the present study, we examined the effect of TRAIL/Apo2L with genistein on the growth of AsPC1 cells in vitro and in vivo. |
| Databáze: |
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