Receptor Subtypes Species Variations in Secretin Affect Potency for Pancreatic but Not Gastric Secretion

Autor: Solomon, Travis E., Keire, David A., Gong, Peixian, Zong, Yumei, Reeve, Joseph R.
Zdroj: Pancreas; April 2003, Vol. 26 Issue: 3 p300-305, 6p
Abstrakt: Receptor subtypes can be distinguished by different actions of agonists on physiologic responses. In this study, we compared effects of four species variants of secretin (rat, porcine, canine, and human) on pancreatic secretion and gastrin-induced acid secretion in urethane-anesthetized rats. These secretins differ by one to three residues in position 14, 15, or 16 and were used to probe for the presence of different secretin receptor subtypes in the rat.
Databáze: Supplemental Index