| Autor: |
Carrazza, Francisco R., Carrazza, Maria Z., Nichols, Veda N., Nichols, Buford L. |
| Zdroj: |
Journal of Pediatric Gastroenterology & Nutrition; February 1989, Vol. 8 Issue: 2 p181-188, 8p |
| Abstrakt: |
Net external acid balance was studied in 12 malnourished infants with chronic diarrhea (some of whom had acquired monosaccharide intolerance). When the infants achieved an adequate energy intake from a formula that contained either glucose or glucose polymers, seven developed metabolic acidosis and Five remained free of acidosis. During the study, the acidotic infants produced a significant excess of acid (3.7 ± 2 vs. 0.5 ± 2 mEq/kg/day, p < 0.005). The amount they excreted in urine (2.9 ± 2 mEq/kg/day), however, was similar to that excreted by nonacidotic infants (2.7 ± 2 mEq/kg/day) and indicated renal inability to reduce the excess acid load. The net effect was hydrogen ion (H +) retention ( + 0.8 ± 0.8 vs. −2.2 ± 0.8 mEq/kg/day, p < 0.001). Good correlation existed between the net acid balance and the acid-base measurement in the blood. We speculate that (a) the increased acid load was a consequence of colonic bacterial production of volatile fatty acids from carbohydrate malabsorbed from the small bowel and (b) the renal incapacity to excrete H +probably was secondary to potassium and phosphate depletion. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
