| Autor: |
Hentges, David J., Marsh, Wallace W., Petschow, Byron W., Thai, Wendy R., Carter, Melody K. |
| Zdroj: |
Journal of Pediatric Gastroenterology & Nutrition; February 1992, Vol. 14 Issue: 2 p146-152, 7p |
| Abstrakt: |
The effect of diet on intestinal ecology was studied in germ-free mice that were inoculated orogastrically with predominant intestinal flora components isolated from the feces of breast-fed human infants. The flora components colonized the intestines of mice and persisted at fixed population levels. Groups of flora- associated mice were fed either human milk, bovine milk, whey-dominant formula, or formula modifications exclusively for 2 weeks, and then examined for changes in small intestinal and cecal flora composition, cecal pH, and resistance to intestinal colonization with Salmonella typhimurium.Dietary variations influenced the composition of the flora to a moderate degree but the differences were generally not statistically significant. However, the addition of bovine lactoferrin to the whey-dominant formula resulted in significantly greater counts of Bifidobacterium, Bacteroides, Enterococcusand total aerobes in the small intestine when compared with mice fed unsup-plemented formula. Bifidobacteriumwas present in large numbers in both the ceca and small intestines of mice fed the lactoferrin-supplemented formula. Despite similarities in intestinal flora patterns among mice fed the various diets, human milk consumption resulted in a lower pH of cecal contents and a greater resistance to colonization by Salmonella typhimuriumafter orogastric challenge than the consumption of the other diets. |
| Databáze: |
Supplemental Index |
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