| Autor: |
LYNN, M. D., GROSS, M. D., SHAPIRO, B. |
| Zdroj: |
Nuclear Medicine Communications; August 1986, Vol. 7 Issue: 8 p625-630, 6p |
| Abstrakt: |
The enterohepatic circulation and distribution of 131I-6β-iodomethyl-19-norcholesterol (NP-59) was assessed in a rabbit model to examine the relative distribution of NP-59 and its metabolites. Adrenal, bile and serum samples were obtained from seven rabbits at 48 h following NP-59 administration (240 to 570 μCi) and the distribution of 131I radioactivity examined using thin layer chromatography. In serum 71 of the radioactivity circulated as NP-59 and 20 as NP-59 esters. In contrast greater than 90 of the adrenal radioactivity was in the form of NP-59 esters while in bile 70 of the activity was NP-59 with the remainder in the form of bile adds. In another group of animals, adrenal activity was observed 5 days after intragastric administration of NP-59. Thus, we have demonstrated a significant enterohepatic circulation of NP-59 that may have the potential to influence the distribution of and resultant adrenal imaging with NP-59. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
