| Autor: |
SHIMPI, H. H., NORONHA, O. P. D., SAMUEL, A. M. |
| Zdroj: |
Nuclear Medicine Communications; October 1995, Vol. 16 Issue: 10 p846-852, 7p |
| Abstrakt: |
Human immunoglobulin (HIG) was labelled with 99Tcmusing different Sn–ligand (methylene diphosphonate, MDP) in high yields. The effect of Sn:ligand ratios and protein (HIG) on the biodistribution pattern of 99Tcm-HIG in an animal model of turpentine-induced inflammatory lesions was studied. 99Tcm-HIG was excreted predominantly via the renal pathway. The use of higher amounts of MDP and HIG resulted in relatively slower blood clearance and increased uptake of 99Tcm-HIG in various organs. Also, higher amounts of ligand [Sn:MDP (1:5)] resulted in significantly greater bone uptake (P< 0.001), while protein caused slower blood clearance and greater liver uptake. Despite the increased uptake of tracer in various organs, the ratio of inflamed:normal muscle uptake did not change significantly. A scintigraphic study was carried out with both 99Tcm-HIG and 99Tcmlabelled with human serum albumin (HSA) in turpentine-induced inflammatory lesions produced in rabbits. The study revealed no significant differences in uptake early on, but the target:non-target ratio was higher with 99Tcm-HIG at 24 h. 99Tcm-HIG also had superior characteristics compared with 99Tcm-HSA. |
| Databáze: |
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