Increasing the radiochemical purity of 99mTc sestamibi commercial preparations results in improved sensitivity of dual-phase planar parathyroid scintigraphy

Autor: Karam, Maroun, Dansereau, Raymond N., Dolce, Charles J., Feustel, Paul J., Robinson, Lawrence W.
Zdroj: Nuclear Medicine Communications; December 2005, Vol. 26 Issue: 12 p1093-1098, 6p
Abstrakt: Poor results for dual-phase parathyroid scintigraphy have recently prompted increased use of dual-tracer imaging. We noticed that seminal studies used higher radiochemical purity than provided by current commercial preparations meeting US Pharmacopea (USP) specifications (90 of technetium bound to sestamibi). We surmised that the presence of unbound Tc (non-MIBI tracer) might hamper dual-phase detection that is dependent on rapid wash-out of technetium from thyroid tissue.
Databáze: Supplemental Index