| Abstrakt: |
Since its introduction in 1988 as a part of the Bethesda System (TBS) for reporting cervical/vaginal diagnoses in gynecologic Papanicolaou tests, the interpretation category of “atypical glandular cells of undetermined significance” has been a source of much discussion and controversy. Although the category is reported in a very small percentage of all Papanicolaou test results (<1%), these cases harbor a high percentage of significant cervical neoplasia. Problems of sampling and poor interobserver agreement of cytologic interpretations have resulted in difficulties in the differential diagnosis of early cervical glandular lesions. Revisions in the 2001 Bethesda System resulted in changes to the cytologic reporting of abnormalities observed in glandular cells, which endeavor to reflect the current knowledge and understanding of glandular neoplasia in the uterine cervix. This paper provides case examples and an overview of the category of “atypical glandular cells” originating in the uterine cervix and its associated pathology. |
