| Autor: |
FEIGHNER, JOHN P., BOYER, WILLIAM F., MEREDITH, CHARLES H., HENDRICKSON, G. GORDON |
| Zdroj: |
International Clinical Psychopharmacology; July 1989, Vol. 4 Issue: 3 p239-244, 6p |
| Abstrakt: |
Fluvoxamine, a selective serotonin reuptake inhibitor, was investigated in a 6-week double-blind study among severely ill inpatients with DSM-III major depression. All but 1 patient also fulfilled criteria for melancholia. Following a 3-day placebo wash-out patients were randomly assigned to fluvoxamine, imipramine or placebo. Sixty of 81 patients completed at least 2 weeks following wash-out and were evaluated for efficacy. Analysis of covariance (controlling for baseline scores) showed significant (p< 0·05) differences on CGI severity and BPRS total and a similar trend (p=0.08) on the Hamilton Depression Scale. Fluvoxamine was superior (p0≤02) to both placebo and imipramine on these measures. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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