| Autor: |
Merz, Ulrich, Kellinghaus, Melanie, Häusler, Martin, Rose, Elmar, Hörnchen, Helmut, Klosterhalfen, Bernd |
| Zdroj: |
Shock; June 2000, Vol. 13 Issue: 6 p472-477, 6p |
| Abstrakt: |
Partial liquid ventilation PLV improves oxygenation in various animal models of respiratory insufficiency. The aim of this study was to compare the effects of conventional ventilation CV, high frequency oscillatory ventilation HFOV, and PLV combined with CV or HFOV on gas exchange and histopathology. Thirty anaesthetised newborn piglets mean weight 1.94 kg, age 1–3 days were randomized in five groups of six animals CV, CV surfactant S, HFOVS, PLVCV, and PLVHFOV. Thirty min after lung injury had been induced with repeated saline lavage, specific ventilatory treatment was initiated. Three animals of the CV group died within the 24 h study period, whereas none died in any of the other groups. The oxygenation index OI and the PaO2FIO2ratio improved significantly within 30 min in all groups, but not in the CV group. After 24 h all oxygenation parameters were better in the PLV groups than in CV or CVS P< 0.05. No differences in gas exchange were noted between HFOVS and PLVCV. The combination of PLV with HFOV led to an increased PaO2FIO2ratio when compared with PLVCV and with HFOVS P< 0.05. All PLV treated animals had significantly less lung injury in the upper and lower lobes compared with gasventilated animals by histologic semiquantitative lung injury score P<0.01 and in the lower lobes by morphometry P<0.001. In conclusion, HFOVS and PLV either with CV or HFOV are effective techniques to provide adequate gas exchange in Sdeficient lungs compared with CV with and without S. However, lung injury was significantly improved in both PLV treated groups compared with HFOVS and the CV groups. |
| Databáze: |
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