Determination of Pentamidine in Whole Blood Plasma and Urine by HighPerformance Liquid Chromatography

Autor: Ericsson, Örjan, Rais, Margareta
Zdroj: Therapeutic Drug Monitoring; July 1990, Vol. 12 Issue: 4 p362-365, 4p
Abstrakt: The analysis of pentamidine in whole blood, plasma, and urine by liquid chromatography is described. Extraction was made with a mixture of acetonitrile and chloroform followed by back-extraction into phosphate buffer. A reversed-phase chromatographic system with fluorescence detection was used. The precision of the method was 5–7 at the lower limit of determination (16 nmol/L in plasma and hemolyzed whole blood, 27.7 nmol/L in urine).
Databáze: Supplemental Index