| Autor: |
Molero, Mariela M., Giulumian, Ararat D., Reddy, Vikram B., Ludwig, Lynda M., Pollock, Jennifer S., Pollock, David M., Rusch, Nancy J., Fuchs, Leslie C. |
| Zdroj: |
Journal of Hypertension; September 2002, Vol. 20 Issue: 9 p1799-1805, 7p |
| Abstrakt: |
The deoxycorticosterone acetate (DOCA)-salt model of hypertension is characterized by elevated vascular endothelin-1 (ET-1) and by reduced contraction to ET-1 in isolated mesenteric small arteries. The decreased contraction to ET-1 may be a compensatory mechanism caused by elevations in ET-1 and arterial pressure. The present study was designed to determine whether down-regulation of endothelin receptors or altered Ca2signaling contribute to the decreased contraction to ET-1. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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