Interaction between lifetime captopril treatment and NaClsensitive hypertension in spontaneously hypertensive rats and Wistar–Kyoto rats

Autor: Fang, Zhiwu, Sripairojthikoon, Wanida, Calhoun, David A., Zhu, Sutao, Berecek, Kathleen H., Wyss, J Michael
Zdroj: Journal of Hypertension; July 1999, Vol. 17 Issue: 7 p983-991, 9p
Abstrakt: Previous studies that were based on daytime arterial pressure recordings indicate that lifetime treatment with captopril exacerbates the hypertensive response to a high NaCl diet in spontaneously hypertensive rats (SHR) but has no such effect in normotensive Wistar–Kyoto (WKY) rats. The present study used 24-h recording methods to examine the hypothesis that during the normal waking hours of rats (night-time) the hypertensive response to a high NaCl diet is exacerbated in SHR and induced in WKY rats treated with lifetime captopril.
Databáze: Supplemental Index