| Autor: |
Shirai, Nobuyuki, Naruko, Takahiko, Ohsawa, Masahiko, Ikura, Yoshihiro, Sugama, Yoshimi, Hirayama, Michihiko, Kitabayashi, Chizuko, Ehara, Shoichi, Inoue, Takeshi, Itoh, Akira, Haze, Kazuo, Tanzawa, Kazuhiko, Yoshiyama, Minoru, Yoshikawa, Junichi, Ueda, Makiko |
| Zdroj: |
Journal of Hypertension; April 2006, Vol. 24 Issue: 4 p711-721, 11p |
| Abstrakt: |
The repair process at the site of injury after percutaneous coronary intervention (PCI) is dominated by neointimal formation composed mainly of smooth muscle cells (SMC). Endothelin-1 (ET-1) is a powerful vasoconstrictor and SMC mitogen. Endothelin-converting enzyme (ECE) is the final key enzyme of endothelin processing. The effects of ET-1 are mediated by binding to endothelin type A (ETA) and endothelin type B (ETB) receptors. The ligand/receptor/ligand-producing system (ET system) could be involved in the pathogenesis of neointimal formation in humans. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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