| Autor: |
Tölle, Markus, Giebing, Günter, Tietge, Uwe JW, Jankowski, Joachim, Jankowski, Vera, Henning, Lars, Hörl, Matthias P, Weiss, Wolfgang, Zidek, Walter, van der Giet, Markus |
| Zdroj: |
Journal of Hypertension; October 2006, Vol. 24 Issue: 10 p1991-2000, 10p |
| Abstrakt: |
Rho-kinase activity is increased in cardiovascular disease and in the pathophysiology of hypertension. Few endogenous factors are known that activate the Rho-kinase pathway. Stimulation of P2Y receptors activates the Rho-kinase pathway. Recently identified diguanosine pentaphosphate (Gp5G) possibly activates P2Y receptors. In this study, Gp5G was identified and quantified in human plasma. The influence of Gp5G on vascular tone was studied. |
| Databáze: |
Supplemental Index |
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