Rat chromosome 19 transfer from SHR ameliorates hypertension, salt-sensitivity, cardiovascular and renal organ damage in salt-sensitive Dahl rats

Autor: Wendt, Norbert, Schulz, Angela, Siegel, Anja-Kristin, Weiss, Judith, Wehland, Markus, Sietmann, Anika, Kossmehl, Peter, Grimm, Daniela, Stoll, Monika, Kreutz, Reinhold
Zdroj: Journal of Hypertension; January 2007, Vol. 25 Issue: 1 p95-102, 8p
Abstrakt: Unlike Dahl salt-sensitive (SS) rats, some strains of spontaneously hypertensive (SHR) rats develop only minor organ damage even when exposed to high-salt diet. In previous linkage studies, we identified quantitative trait loci on rat chromosome 19 (RNO19) linked to the SHR allele suggesting a protective effect against salt-induced hypertensive organ damage in SS.
Databáze: Supplemental Index