| Autor: |
Zijl, Nynke J. van der, Serné, Erik H., Goossens, Gijs H., Moors, Chantalle C.M., IJzerman, Richard G., Blaak, Ellen E., Diamant, Michaela |
| Zdroj: |
Journal of Hypertension; October 2011, Vol. 29 Issue: 10 p1955-1962, 8p |
| Abstrakt: |
Individuals with impaired glucose metabolism (IGM) are at high risk of developing type 2 diabetes (T2DM). The renin–angiotensin system (RAS) is activated in insulin-resistant states and its inhibition resulted in delayed onset of T2DM. The underlying mechanisms may include improvement in microvascular structure and function, which may increase glucose and insulin delivery to insulin-sensitive tissues. We hypothesized that functional and structural capillary density is impaired in insulin-resistant individuals with IGM and that treatment with the angiotensin-receptor blocker valsartan (VAL) will improve insulin sensitivity and microvascular function. |
| Databáze: |
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