| Autor: |
Liang, Wenbin, Huang, Lihong, Zhao, Dongling, He, Jeff Z., Sharma, Parveen, Liu, Jie, Gramolini, Anthony O., Ward, Michael E., Cho, Hee Cheol, Backx, Peter H. |
| Zdroj: |
Journal of Hypertension; February 2014, Vol. 32 Issue: 2 p318-330, 13p |
| Abstrakt: |
Proliferation of pulmonary artery smooth muscle cells (PASMCs) leads to adverse vascular remodeling and contributes to pulmonary arterial hypertension, a condition associated with a 15 annual mortality despite treatment. We previously showed that swelling-activated Cl−currents (ICl,swell) are upregulated in PASMC proliferation and that nonspecific Cl−current blockers inhibit proliferation. However, the specific role of ICl,swellin PASMC proliferation and its molecular underpinning remain unknown. |
| Databáze: |
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