| Autor: |
Hesselink, Dennis A., Schaik, Ron H.N. van, van Agteren, Madelon, Fijter, Johannes W. de, Hartmann, Anders, Zeier, Martin, Budde, Klemens, Kuypers, Dirk R.J., Pisarski, Przemyslav, Meur, Yann Le, Mamelok, Richard D., van Gelder, Teun |
| Zdroj: |
Pharmacogenetics and Genomics; April 2008, Vol. 18 Issue: 4 p339-348, 10p |
| Abstrakt: |
Patients expressing the tacrolimus-metabolizing enzyme, cytochrome P450 (CYP) 3A5, require more tacrolimus to reach target concentrations. We studied the influence of the CYP3A53allele, which results in the absence of CYP3A5 protein, on tacrolimus dose and exposure, as well as the incidence of biopsy-proven acute rejection (BPAR) after renal transplantation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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