Population differences in platinum toxicity as a means to identify novel genetic susceptibility variants

Autor: O'Donnell, Peter H., Gamazon, Eric, Zhang, Wei, Stark, Amy L., Kistner-Griffin, Emily O., Stephanie Huang, R., Eileen Dolan, M.
Zdroj: Pharmacogenetics and Genomics; May 2010, Vol. 20 Issue: 5 p327-337, 11p
Abstrakt: Clinical studies show that Asians (ASN) are more susceptible to toxicities associated with platinum-containing regimens. We hypothesized that studying ASN as an ‘enriched phenotype’ population could enable the discovery of novel genetic determinants of platinum susceptibility.
Databáze: Supplemental Index