| Autor: |
Woodard-Grice, Alencia V., Lucisano, Amelia C., Byrd, James B., Stone, Elizabeth R., Simmons, William H., Brown, Nancy J. |
| Zdroj: |
Pharmacogenetics and Genomics; September 2010, Vol. 20 Issue: 9 p532-536, 5p |
| Abstrakt: |
Angioedema is a rare adverse effect of angiotensin-converting enzyme (ACE) inhibitors, which occurs more commonly in women and black Americans. Angioedema is thought to result from decreased degradation of vasoactive peptides. During ACE inhibition, bradykinin is primarily inactivated by aminopeptidase P (APP). Earlier studies have provided conflicting data with regard to serum APP activity in patients with a history of ACE inhibitor-associated angioedema. A single nucleotide polymorphism, -2399C>A (rs3788853, C-2399A), in XPNPEP2, the X-linked gene that encodes membranous APP, has been reported to associate with APP activity. |
| Databáze: |
Supplemental Index |
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