Adenosine A2Areceptor gene polymorphism (1976C>T) affects coronary flow reserve response during vasodilator stress testing in patients with non ischemic-dilated cardiomyopathy

Autor: Andreassi, Maria Grazia, Laghi Pasini, Franco, Picano, Eugenio, Capecchi, Pier Leopoldo, Pompella, Gerarda, Foffa, Ilenia, Borghini, Andrea, Sicari, Rosa
Zdroj: Pharmacogenetics and Genomics; August 2011, Vol. 21 Issue: 8 p469-475, 7p
Abstrakt: Patients with non ischemic-dilated cardiomyopathy (DCM) are characterized by an activation of the adenosinergic system and reduced coronary flow reserve (CFR) evaluated by transthoracic Doppler echocardiography during vasodilator adenosinergic stress (dipyridamole administration). The aim of this study was to assess whether genetic polymorphisms (263C>T and 1976C>T) of the A2Areceptor gene affect CFR response in patients with DCM.
Databáze: Supplemental Index