| Autor: |
Pendlington, Ruth U., Brown, Elizabeth J., Sanders, David J., Minter, Helen M., Hyde, Simon, Snow, Mary, Smith Pease, Camilla K. |
| Zdroj: |
Cutaneous and Ocular Toxicology (formerly Journal of Toxicology - Cutaneous and Ocular Toxicology); 2003, Vol. 22 Issue: 3 p117-124, 8p |
| Abstrakt: |
Diethylenetriaminepenta-acetic acid (DTPA) is a metal ion-chelating agent that has antimicrobial properties and potential therapeutic properties against metal-induced toxicities such as nickel allergy. In this study, the absorption properties of DTPA applied topically to rat skin are investigated in vitro, using a flow-through diffusion skin absorption model. [14C]DTPA was applied in solution in 60% ethanol (pH 6). Overall skin penetration into receptor fluid resulting from a topical dose of 0.13 mgcm2DTPA for 24 h was low at 1.27%. The local tissue distribution of DTPA was investigated using microautoradiography, and effects on the tissue were assessed by histology. Diethylenetriaminepenta-acetic acid was primarily associated with the stratum corneum and upper layers of the skin; minimal levels were observed in the dermis. |
| Databáze: |
Supplemental Index |
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