| Autor: |
Lee, Christopher R., Guivarch, Florence, Dau, Céline Nguyen Van, Tessier, Dominique, Krstulovic, Ante M. |
| Zdroj: |
Analyst; 2003, Vol. 128 Issue: 7 p857-863, 7p |
| Abstrakt: |
We report a new method for the determination of the methyl, ethyl and isopropyl esters of methanesulfonic acid, and of dimethyl sulfate. Derivatisation with aqueous sodium thiocyanate gives a mixture of the corresponding alkylthiocyanates and alkylisothiocyanates which, unlike the underivatised analytes, are readily analysed by GC. On-column isomerisation is negligible. These lower alkyl derivatives are sufficiently volatile for static reaction headspace analysis, and detection limits obtained by electron impact MS are below 0.05 µg ml−1 with respect to the injection solution. The method was used to demonstrate that levels of methanesulfonic acid esters in a drug substance (a mesylate salt that had been processed using methanol and ethanol) are below 1 µg g−1. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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