| Autor: |
Ozkul, Yilmaz, Songu, Murat, Basoglu, Mehmet Sinan, Ozturkcan, Sedat, Katilmis, Huseyin |
| Zdroj: |
Journal of Craniofacial Surgery; July 2014, Vol. 25 Issue: 4 p1515-1518, 4p |
| Abstrakt: |
The aim of our study was to determine the effectiveness of intratympanic -lipoic acid injection as an otoprotective agent against cisplatin-induced ototoxicity in guinea pigs. Twenty-four adult male albino guinea pigs with normal hearing were divided into 4 groups. The guinea pigs received intraperitoneal cisplatin in group 1, intraperitoneal cisplatin and intratympanic -lipoic acid in group 2, intratympanic -lipoic acid in group 3, as well as intraperitoneal cisplatin and intratympanic saline in group 4. Distortion-product otoacoustic emission measurements were obtained for both ears at the following time points: before administration (baseline recording) and on day 3 (72 h later). In group 1 (cisplatin), significant deterioration was observed at all frequencies on day 3 (P< 0.05). In group 2 (cisplatin -lipoic acid), deterioration was observed at all frequencies on day 3; however, this deterioration did not reach a statistical significance (P> 0.05). In group 3 (-lipoic acid), no significant difference was observed between baseline and day 3 (P> 0.05). In group 4 (cisplatin saline), deterioration was observed at all frequencies on day 3; however, this deterioration did not reach a statistical significance (P> 0.05). Cisplatin-induced hearing loss in the guinea pigs may be limited to some extent by the concomitant use of -lipoic acid. Dose-dependent changes in the possible effects of -lipoic acid need further investigation. Future morphologic studies may contribute to expose clearly the protective effect of -lipoic acid. |
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