| Autor: |
Gut, André, Moch, Holger, Choschzick, Matthias |
| Zdroj: |
International Journal of Gynecological Pathology; January 2018, Vol. 37 Issue: 1 p68-73, 6p |
| Abstrakt: |
SOX2 (SRY-related HMG-box 2)belongs to the SOXgene family of high-mobility transcription factors indispensably involved in gene regulation in pluripotent stem cells and neural differentiation. SOX2copy number increases have been frequently reported in various types of squamous cell cancer. To better understand the effect of SOX2aberrations on vulvar cancer phenotype and patient prognosis, we analyzed SOX2copy number changes using fluorescence in situhybridization and SOX2 expression by immunohistochemistry in 55 squamous cell carcinomas of the vulva. SOX2amplification was found in 20.8% of tumors; 27.3% of vulvar carcinomas showed SOX2 protein overexpression. SOX2amplification was correlated with SOX2 overexpression in our data set (P<0.01). Amplification of the SOX2locus was associated with high tumor grade (P<0.05) and human papillomavirus (HPV) positivity (P<0.01). SOX2-amplified tumors showed more frequently a basaloid phenotype than nonamplified carcinomas. SOX2 protein overexpression was also correlated with basaloid phenotype and positive HPV status of vulvar carcinomas (P<0.05, each). SOX2amplification and expression were not associated with patient overall survival. In conclusion, SOX2copy number increases are detectable in a substantial proportion of high-grade HPV-positive vulvar carcinomas with basaloid differentiation. Our study provides further evidence for different molecular alterations in HPV-positive and HPV-negative vulvar carcinomas. |
| Databáze: |
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