| Autor: |
Kaijzel, Eric L., Heijningen, Paula M. van, Wielopolski, Piotr A., Vermeij, Marcel, Koning, Gerben A., Cappellen, Wiggert A. van, Que, Ivo, Chan, Alan, Dijkstra, Jouke, Ramnath, Natasja W.M., Hawinkels, Lukas J.A.C., Bernsen, Monique R., Löwik, Clemens W.G.M., Essers, Jeroen |
| Zdroj: |
Circulation: Cardiovascular Imaging; September 2010, Vol. 3 Issue: 5 p567-577, 11p |
| Abstrakt: |
We imaged the protease activity of matrix metalloproteinases (MMPs) upregulated during aneurysm formation, using protease-activatable near-infrared fluorescence probes. We tested whether these protease-activatable sensors can directly report the in vivo activity of the key biomarkers in aneurysm, using our genetically modified fibulin-4 mouse models for aneurysm formation. Mice homozygous for the fibulin-4 reduced-expression allele (fibulin-4RR) show dilatation of the ascending aorta and a tortuous, stiffened aorta resulting from disorganized elastic fiber networks. Strikingly, even a moderate reduction in expression of fibulin-4 in the heterozygous fibulin-4Rmice occasionally results in modest aneurysm formation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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