| Autor: |
Chen, Gaopeng, Li, Sen, Karakikes, Ioannis, Ren, Lihuan, Zi-Ying Chow, Maggie, Chopra, Anant, Keung, Wendy, Yan, Bin, Chan, Camie W.Y., Costa, Kevin D., Kong, Chi-Wing, Hajjar, Roger J., Chen, Christopher S., Li, Ronald A. |
| Zdroj: |
Circulation: Arrhythmia and Electrophysiology; February 2015, Vol. 8 Issue: 1 p193-202, 10p |
| Abstrakt: |
Human (h) embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) serve as a potential unlimited ex vivo source of cardiomyocytes (CMs). However, a well-accepted roadblock has been their immature phenotype. hESCiPSC-derived ventricular (v) CMs and their engineered cardiac microtissues (hvCMTs) similarly displayed positive chronotropic but null inotropic responses to -adrenergic stimulation. Given that phospholamban (PLB) is robustly present in adult but poorly expressed in hESCiPSC-vCMs and its defined biological role in -adrenergic signaling, we investigated the functional consequences of PLB expression in hESCiPSC-vCMs and hvCMTs. |
| Databáze: |
Supplemental Index |
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