BRAFMutations in Colorectal Cancer Are Associated With Distinct Clinical Characteristics and Worse Prognosis

Autor: Kalady, Matthew F., DeJulius, Kathryn L., Sanchez, Julian A., Jarrar, Awad, Liu, Xiuli, Manilich, Elena, Skacel, Marek, Church, James M.
Zdroj: Diseases of the Colon and Rectum; February 2012, Vol. 55 Issue: 2 p128-133, 6p
Abstrakt: Colorectal cancer is a heterogeneous disease with multiple underlying genetic mutations causing different clinical phenotypes. Mutation in the BRAFoncogene is a key step in malignant transformation within the methylator pathway to colorectal cancer. However, there is a paucity of information about BRAFmutant colorectal tumors.
Databáze: Supplemental Index