Proximal Cerebral Arteries Develop Myogenic Responsiveness in Heart Failure via Tumor Necrosis Factor-–Dependent Activation of Sphingosine-1-Phosphate Signaling

Autor: Yang, Jingli, Hossein Noyan-Ashraf, M., Meissner, Anja, Voigtlaender-Bolz, Julia, Kroetsch, Jeffrey T., Foltz, Warren, Jaffray, David, Kapoor, Amita, Momen, Abdul, Heximer, Scott P., Zhang, Hangjun, van Eede, Matthijs, Henkelman, R. Mark, Matthews, Stephen G., Lidington, Darcy, Husain, Mansoor, Bolz, Steffen-Sebastian
Zdroj: Circulation (Ovid); July 2012, Vol. 126 Issue: 2 p196-206, 11p
Abstrakt: Heart failure is associated with neurological deficits, including cognitive dysfunction. However, the molecular mechanisms underlying reduced cerebral blood flow in the early stages of heart failure, particularly when blood pressure is minimally affected, are not known.
Databáze: Supplemental Index