Intraoperative Magnesium Administration Does Not Improve Neurocognitive Function After Cardiac Surgery

Autor: Mathew, Joseph P., White, William D., Schinderle, David B., Podgoreanu, Mihai V., Berger, Miles, Milano, Carmelo A., Laskowitz, Daniel T., Stafford-Smith, Mark, Blumenthal, James A., Newman, Mark F., Mathew, Joseph P., Blumenthal, James A., Fontes, Manuel A., Kertai, Miklos D., Lombard, Frederick W., Mathew, Joseph P., McDonagh, David L., Monk, Terri G., Newman, Mark F., Podgoreanu, Mihai V., Stafford-Smith, Mark, Swaminathan, Madhav, Warner, David S., Funk, Bonita L., Balajonda, Narai, Hall, Roger L., Bisanar, Tiffany, Clemmons, Karen L., Li, Yi-Ju, Pecora, Greg, Phillips-Bute, Barbara, Toulgoat-Dubois, Yanne, Waweru, Peter, White, William D., Babyak, Michael A., Blumenthal, James A., Browndyke, Jeffrey N., Welsh-Bohmer, Kathleen A., Mark, Daniel B., Sketch, Michael H., Bennett, Ellen R., Graffagnino, Carmelo, Laskowitz, Daniel T., Strittmatter, Warren J., Alexander, Stanlin, Collins, Kevin, Smigla, Greg, Shearer, Ian, Berry, Mark F., D’Amico, Thomas A., Daneshmand, Mani A., Davis, R. Duane, Gaca, Jeffrey G., Glower, Donald D., Harpole, R. David, Hughes, G. Chad, Jaquiss, Robert D.B., Lin, Shu S., Lodge, Andrew J., Milano, Carmelo A., Onaitis, Mark W., Schroeder, Jacob N., Smith, Peter K., Tong, Betty C.
Zdroj: Stroke (Ovid); December 2013, Vol. 44 Issue: 12 p3407-3413, 7p
Abstrakt: Neurocognitive decline occurs frequently after cardiac surgery and persists in a significant number of patients. Magnesium is thought to provide neuroprotection by preservation of cellular energy metabolism, blockade of the N-methyl-D-aspartate receptor, diminution of the inflammatory response, and inhibition of platelet activation. We therefore hypothesized that intraoperative magnesium administration would decrease postoperative cognitive impairment.
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