| Autor: |
Yang, Zhong-Tao, Zhao, Jianhong, Yang, Wu-Lin, Deng, Wei-Ping |
| Zdroj: |
Organic Letters; January 2019, Vol. 21 Issue: 4 p1015-1020, 6p |
| Abstrakt: |
A highly enantioselective Michael/lactonization cascade reaction of 3-hydroxyoxindoles with 3-trifluoroethylidene oxindoles was developed. The use of a cinchona-derived squaramide catalyst is essential in achieving high diastereo- and enantioselectivities. This reaction represents the first example of intramolecular amide C–N bond cleavage and lactonization of 3-hydroxyoxindoles with 3-trifluoroethylidene oxindoles, which provides an efficient and convenient approach to diverse CF3-containing spirooxindole γ-lactones in high yields and good to excellent diastereo- and enantioselectivities. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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