| Autor: |
Rezaei, Mahnaz, Mohammadpour-Gharehbagh, Abbas, Narooei-nejad, Mehrnaz, Teimoori, Batool, Mokhtari, Mojgan, Mehrabani, Mehrnaz, Yaghmaei, Minoo, Najafi, Darya, Salimi, Saeedeh |
| Zdroj: |
Journal of Human Hypertension; July 2019, Vol. 33 Issue: 7 p552-558, 7p |
| Abstrakt: |
Evidence showed that microRNA biosynthesis plays the main role in pathogenesis of several diseases including Preeclampsia (PE). Therefore, microRNA processing enzymes may involve in PE predisposition. The aim of the present study was to evaluate the relation between DROSHArs10719 and rs6877842 polymorphisms and mRNA expression in the placenta of PE women and controls. This study recruited 110 PE women and 115 age matched normotensive pregnant women for genotyping of DROSHApolymorphisms and analyzing of mRNA expression. There was no association between alleles and genotypes of placental DROSHArs10719 and rs6877842 polymorphisms and PE susceptibility. However, placental DROSHArs10719 was associated with increased PE risk in the recessive model. The combination of CC/GG genotypes of DROSHArs10719 and rs6877842 polymorphisms was associated with higher risk of PE. The frequency of C-G haplotype was higher in PE women, but the difference was not significant. The DROSHAmRNA expression was downregulated in the placenta of PE women. There was no relation between DROSHAmRNA expression and rs6877842 polymorphism, however, it was decreased in the placenta of women with rs10719CC genotype. The placental DROSHArs10719 but not rs6877842 polymorphism could be a risk factor for PE susceptibility only in the recessive model. The combination of CC/GG genotypes could be risk factors for PE susceptibility. The DROSHAexpression downregulated in the preeclamptic placentas and those carrying rs10719CC genotype. |
| Databáze: |
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