Isospora belliinfection A report of two cases in patients with AIDS

Autor: Lumb, Richard, Hardiman, Robyn
Zdroj: Medical Journal of Australia; August 1991, Vol. 155 Issue: 3 p194-196, 3p
Abstrakt: Objective:To present the findings of Isospora belliinfection in two patients with the acquired immunodeficiency syndrome (AIDS). Clinical features:One patient was part Aboriginal, the other an immigrant recently arrived from Peru. Both men were infected with the human immunodeficiency virus (HIV). They presented with watery diarrhoea, one with severe weight loss. Isospora bellioocysts were detected in multiple faecal specimens from both patients. One patient had a concomitant infection with Cryptosporidiumsp. Intervention and outcome:There was a rapid response to treatment with co‐trimoxazole (960 mg, four times a day for 10 days). A complete response was obtained in the patient with concurrent cryptosporidiosis. The diarrhoea recurred after cessation of treatment, necessitating maintenance therapy. Conclusion:Although Isospora belliis an uncommon cause of gastroenteritis in Australia, it is increasingly recognised as a cause of diarrhoea in travellers, immigrants from endemic areas and immunocompromised people. It has also been reported in the Aboriginal community; this article reports the first case of AIDS‐related isosporiasis in an Aborigine. It is likely that both patients acquired Isospora bellibefore they become HIV seropositive.
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