| Autor: |
Reed, Carson W., Yohn, Samantha E., Washecheck, Jordan P., Roenfanz, Hanna F., Quitalig, Marc C., Luscombe, Vincent B., Jenkins, Matthew T., Rodriguez, Alice L., Engers, Darren W., Blobaum, Anna L., Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W. |
| Zdroj: |
Journal of Medicinal Chemistry; February 2019, Vol. 62 Issue: 3 p1690-1695, 6p |
| Abstrakt: |
Herein, we report the discovery of a new, orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 (mGlu7) negative allosteric modulator (NAM) that achieves exposure in cerebral spinal fluid (CSF) 2.5× above the in vitro IC50at minimum effective doses (MEDs) of 3 mg/kg in preclinical anxiety models. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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