| Autor: |
Helaly, Soleiman E., Hamad, Zainab, El Sayed, Magdi A., Abdel-Motaal, Fatma F., Nassar, Mahmoud I., Ito, Shin-ichi, Stadler, Marc |
| Zdroj: |
Zeitschrift für Naturforschung C; December 2018, Vol. 74 Issue: 1-2 p55-59, 5p |
| Abstrakt: |
A strain of Bacillus methylotrophicuswas isolated from a soil sample collected in Aswan eastern desert, which is known for its extremely arid climate. After fermentation of the strain in liquid culture and subsequent extraction, a bioassay-guided isolation procedure yielded five compounds: 2-benzyl-4H-pyran-4-one, named bacillopyrone (1), pyrophen (2), macrolactin A (3) and the cyclopeptides malformin A1 (4), and bacillopeptin A (5). The structures were determined by interpretation of nuclear magnetic resonance (NMR) spectroscopy and high resolution mass spectrometry (HR-MS) data. This is the first report on the isolation of compounds 1and 2from Bacillusspecies; compound 1 was reported previously as synthetic product. Bacillopyrone (1) exhibited moderate activity against the Gram-negative Chromobacterium violaceumwith minimum inhibitory concentration 266.6 μg/mL, while macrolactin A (3) and malformin A1 (4) inhibited Staphylococcus aureus(minimum inhibitory concentrations 13.3 and 133.3 μg/mL, respectively). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
