| Autor: |
LUNDBORG, G., ZHAO, Q., KANJE, M., DANIELSEN, N., KERNS, J. M. |
| Zdroj: |
Journal of Hand Surgery (European Volume); June 1994, Vol. 19 Issue: 3 p277-282, 6p |
| Abstrakt: |
The possibility that collateral sprouting could occur from intact axons in au undamaged sciatic nerve was studied in the rat by suturing either a 7-day predegenerated or a fresh nerve segment in an end-to-side fashion to the sciatic nerve proper. Following a 14- or 35-day recovery period, the pinch reflex test was performed on the transplanted segment to demonstrate the presence of sensory axons. The majority of cases, using a predegenerated nerve segment hut not a fresh segment, responded positively. Neurofilament staining and histological examination confirmed the presence of axons in the attached nerve segment. In another series of experiments, the proximal peroneal fascicle was ligated and cut. Following a 7-day predegeneration period the distal stump was sutured end-to-side to the ipsilateral tibia1 fascicle. After 90 days, stimulation of the tibia1 nerve proximal to the attached site induced substantial contraction in both the native gastrocnemius muscle and the foreign tibialis anterior muscle. These findings suggest that collateral sprouting may occur from intact axons, perhaps induced by factors emanating from the attached nerve segment, and subsequently make functional peripheral connections. |
| Databáze: |
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