Comparison of Pharmacist-Directed Management of Multiplex PCR Blood Culture Results with Conventional Microbiology Methods on Effective and Optimal Therapy within a Community Hospital

Autor: Porter, Allison M., Bland, Christopher M., Young, Henry N., Allen, David R., Croft, Sabrina R., Gayheart, R. Ellen, Miller, Parks W., Musgrove, Rachel J., Robertson, Emilee M., Gibson, Geneen M.
Zdroj: Antimicrobial Agents and Chemotherapy; October 2018, Vol. 63 Issue: 1
Abstrakt: Multiplex PCR combined with a pharmacist-driven reporting protocol was compared to the standard of care within a community hospital to evaluate initial changes after notification of a positive blood culture. The intervention group demonstrated decreased times to changes in antimicrobial therapy (P= 0.0081), increased changes to optimal antimicrobial therapy (P= 0.013), and decreased vancomycin use for coagulase-negative staphylococcus contaminants (P< 0.01) with multiplex PCR implementation and pharmacist intervention.
Databáze: Supplemental Index