| Autor: |
Babouri, Rachida, Traore, Lanciné, Bekro, Yves-Alain, Matveeva, Victoria I., Sadykova, Yulia M., Voronina, Julia K., Burilov, Alexander R., Ayad, Tahar, Volle, Jean-Noël, Virieux, David, Pirat, Jean-Luc |
| Zdroj: |
Organic Letters; December 2018, Vol. 21 Issue: 1 p45-49, 5p |
| Abstrakt: |
Reported herein is the first example of a gold-catalyzed cyclization of bis(arylmethyl)ethynylphosphine oxides. This represents an original approach to bridgehead methanophosphocines 1, eight-membered heterocycles. Gold catalyst in combination with triflic acid activates alkyne and induces a double hydroarylation. Mechanistic studies suggest that the reaction proceeds stepwise, forming first the 1H-isophosphinoline 2-oxide 5. Reduction and protection of the corresponding phosphine oxides 1described herein also highlight the effectiveness of our approach to this new class of electron-rich ligands. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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