| Autor: |
Clements, M.R., Chalmers, T.M., Fraser, D.R. |
| Zdroj: |
The Lancet; June 1984, Vol. 323 Issue: 8391 p1376-1379, 4p |
| Abstrakt: |
Vitamin-D metabolites in bile were investigated after oral and intravenous doses of radioactively labelled vitamin D had been given to six patients with T-tube biliary drainage after cholecystectomy. The vitamin was mainly excreted as highly polar inactivation products and less than 4% of the metabolites in bile were present as 25-hydroxyvitamin D or its glucuronide conjugate. There was insufficient vitamin D or 25-hydroxyvitamin D in bile for the reabsorption of these metabolites to make a significant contribution to normal vitamin-D status. Therefore interference with an enterohepatic circulation of vitamin-D metabolites cannot be a cause of vitamin-D deficiency. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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