| Autor: |
Lund, B., Kjaer, I., Friis, T., Hjorth, L., Reimann, I., Andersen, R.B., Sørensen, O.H. |
| Zdroj: |
The Lancet; December 1975, Vol. 306 Issue: 7946 p1168-1171, 4p |
| Abstrakt: |
Seven patients with osteoporosis of ageing were treated with synthetic 1α-hy- droxycholecalciferol (1α-H.C.C.) for 3-4 months. The compound was given at a daily oral dose of 2 μg together with an oral supplement of 1 g of calcium. Clinically there was a striking improvement in the patients' physical fitness. Increased bone formation and mineralisation were seen on iliac-crest bone biopsy, and this was supported by an increased osteoblastic activity demonstrated by histochemical measurement of alkaline-phosphatase activity. Bone histology furthermore showed a reduced bone resorption, which was supported by a reduced urinary excretion of total hydroxyproline. Photon absorptiometry of the forearm accorded with the histological findings, showing a significant increase in the bone mineral content. Serum-calcium rose in all patients, one developing a severe transitory hypercalcæmia. The urinary excretion of calcium and magnesium increased significantly. The serum concentrations of 25-hydroxycholecalciferol and parathyroid hormone were not significantly affected by the treatment. It is concluded that 1α-H.C.C. is an effective tool in the treatment of senile osteoporosis. |
| Databáze: |
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