RELATION BETWEEN PLASMA ŒSTRONE AND ŒSTRADIOL AND CLIMACTERIC SYMPTOMS

Autor: Hutton, J.D., Murray, M.A.F., Jacobs, H.S., James, V.H.T.
Zdroj: The Lancet; April 1978, Vol. 311 Issue: 8066 p678-681, 4p
Abstrakt: Plasma levels of œstrone and œstradiol-17β were determined at 20 or 30 minute intervals for up to 24 hours in 26 postmenopausal or ovariectomised women of similar age, weight, and number of years since menopause or operation. Results in women with both superficial dyspareunia and flushes were compared with those in women with flushes only, and with those in symptomless women. Women with superficial dyspareunia had significantly lower mean concentrations of plasma-œstradiol, but not of œstrone, than symptomless women. Flushes were not related to plasma-œstrogen. The implications of these findings in relation to the optimum dose of œstrogen for treating climacteric symptoms are discussed.
Databáze: Supplemental Index