| Autor: |
Marmion, B.P., Kyrkou, M., Worswick, D., Esterman, A., Ormsbee, R.A., Wright, J., Cameron, S., Feery, B., Collins, W. |
| Zdroj: |
The Lancet; December 1984, Vol. 324 Issue: 8417-8418 p1411-1414, 4p |
| Abstrakt: |
Q fever is an important cause of morbidity in Australian meatworkers; recently there have been sharp outbreaks of Q fever in abattoirs in several states. In an attempt to control Q fever by vaccination, 924 nonimmune volunteers at two South Australian abattoirs were inoculated with one dose of a purified, formalin-inactivated, Coxiella burneti,Henzerling strain, phase 1 vaccine. Some 56% of workers in one abattoir, and 64% in the other, seroconverted after vaccination. In the 18 months after vaccination, no Q fever occurred in fully vaccinated subjects, whereas there were 34 cases in 1349 unvaccinated workers. Transient local reactions were noted in most vaccinated subjects; only a few had mild general reactions. No cases of vaccine-enhanced disease were observed. Vaccination of susceptible individuals with a purified C burnetiphase 1 vaccine appears to be safe and effective in preventing Q fever in the abattoir. |
| Databáze: |
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