| Autor: |
Elmazar, M.M.A., McElhatton, Patricia R., Sullivan, F.M. |
| Zdroj: |
Human and Experimental Toxicology; January 1981, Vol. 1 Issue: 1 p53-63, 11p |
| Abstrakt: |
1In Charles River CD 1 mice, a single dose of 100 mg kg-1caffeine injected intraperitoneally on day 14 of pregnancy caused a low incidence of cleft palate in the fetuses.2Single oral doses of caffeine of 200 and 300 mg kg-1but not 100 mg kg-1on day 14, caused cleft palate in some of the fetuses, but was clearly toxic to the dams.3Oral doses of caffeine up to 300 mg kg-1on day 14 of pregnancy did not reduce utero-placental blood flow, placental transfer function, or amniotic fluid volume.4An oral dose of 100 mg kg-1caffeine induced a marked stimulation of adrenocortical secretion producing plasma corticosterone levels of 1248 ± 129 ?g per 100 ml by 2 h and with elevated levels persisting more than 8 h.5It is suggested that the elevated plasma corticosterone is the cause of the cleft palate induced in mice by caffeine. Since corticosterone is a known cleft palate inducer in mice but not in man these results do not predict a hazard from normal caffeine consumption in man. |
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