Diethylphosphoryl-OxymaB (DEPO-B) as a Solid Coupling Reagent for Amide Bond Formation

Autor: Kumar, Ashish, Jad, Yahya E., El-Faham, Ayman, Torre, Beatriz G. de la, Albericio, Fernando
Zdroj: Letters in Organic Chemistry; January 2019, Vol. 16 Issue: 1 p30-33, 4p
Abstrakt: A new phosphonium based coupling reagent DEPO-B has been synthesized from 5- (hydroxyimino)-1,3-dimethylpyrimidine-2,4,6 (1H,3H,5H)-trione (Oxyma B) and diethyl chlorophosphate in presence of base. It is a solid material and the hydrolytic stability and solubility was evaluated for confirming its capability for usage in automated peptide synthesizer.
Databáze: Supplemental Index