SERUM-CREATINE-KINASE IN CASES OF STROKE, HEAD INJURY, AND MENINGITIS

Autor: Dubo, H., Park, DorothyC., Pennington, R.J.T., Kalbag, R.M., Walton, JohnN.
Zdroj: The Lancet; October 1967, Vol. 290 Issue: 7519 p743-748, 6p
Abstrakt: The serum-creatine-kinase (C.K.) was studied in cases of head injury, acute cerebrovascular accident, and meningitis. Each of 14 patients with a head injury had raised serum-C.K. values. Of 21 patients with acute strokes, 15 had raised values. Of 7 patients with meningitis, 2 had raised values. In all patients having sufficiently high levels of serum-C.K. for isoenzyme fractionation, the circulating enzyme was found to be derived largely from muscle. No definite clinical correlations or prognostic inferences could be determined from the serum-C.K. levels. There is no clear evidence that this enzyme leaks from the brain into the blood-serum in any of the neurological disorders studied. Why muscle C.K. is often much increased in the serum in such cases remains unclear.
Databáze: Supplemental Index